Dr Dayan Goodenow - Plasmalogens - Latest Science. Fix and Prevent our scariest, deadliest diseases

About

I believe that disease is predictable and that the leading cause of death is ignorance and inaction.

My mission is to change the status quo, go beyond the diagnosis of disease, and advance precision preventative medicine into mainstream medical practice.

Over the past 30 years, I have invented and developed advanced diagnostic and bioinformatic technologies, designed and manufactured novel and natural biochemical precursors, and identified a treasure trove of biochemical markers that predict numerous diseases including Alzheimer’s and dementia, Parkinson’s, multiple sclerosis, stroke, autism, ALS, multiple system atrophy, various mental illnesses, and cancers.

The study of Plasmalogens is vital in predicting several diseases. Plasmalogens are critical membrane components that help cells communicate with each other and function harmoniously. I have studied Plasmalogens since 2006, and research has expanded to show that Plasmalogens are the root cause of neurodegeneration that leads to Alzheimer’s, Parkinson’s, and MS.

My passion is to educate the world about the life-extending benefits possible when Plasmalogen health is harnessed.

I have released over 50 scientific publications, with research on over 25 diseases and have over 30 Academic Collaborations worldwide. I have extensively patented my inventions including patents for Plasmalogen Compounds, Pharmaceutical Compositions, and treatment methods for age related diseases that are mediated by Plasmalogen Deficiencies.

My focus, As the founder and CEO of Prodrome Sciences Inc., is to build a next-generation team of dedicated researchers and medical professionals who are determined to maximize longevity for millions of people around the world.

Currently, I have over 10 clinical trials ongoing with over 8,000 people globally. These trials are focused on various aspects of aging and diseases such as various cancers, Alzheimer’s disease and dementia, Parkinson’s disease, schizophrenia, bipolar disorder, and depression.

I have extensive experience compiling and training teams of professionals. I have built ISO certified, FDA compliant manufacturing facilities, CAP/CLIA certified laboratories, and advanced programs for researching the biochemical mechanisms and causes of human health disorders and developing diagnostic and treatment solutions for them.

Plasmalogens are a type of phospholipid found in cell membranes, particularly in the brain, heart, and liver. They are unique in that they contain a vinyl ether bond in the sn-1 position of the glycerol backbone, whereas most phospholipids contain a ester bond in this position. Plasmalogens play important roles in cellular function, including maintaining membrane fluidity and stability, acting as precursors for signaling molecules, and serving as a source of energy for cells. They also have antioxidant properties, helping to protect cells against oxidative stress. Studies have shown that a decrease in plasmalogen levels is associated with several diseases, including Alzheimer's disease, cardiovascular disease, and nonalcoholic fatty liver disease. Researchers are exploring the potential of plasmalogen supplementation as a therapeutic strategy for these and other conditions. Despite their importance, the biosynthesis of plasmalogens is not well understood. Further research is needed to fully understand the role of plasmalogens in health and disease, and to develop effective strategies for restoring plasmalogen levels in individuals with plasmalogen deficiency. Understanding Plasmalogens: Key Components of Cell Membranes Plasmalogens are a type of phospholipid found in cell membranes, playing crucial roles in maintaining cellular function and protecting against oxidative stress. Despite their importance, the biosynthesis of plasmalogens is not well understood and further research is needed to fully comprehend their role in health and disease. What are Plasmalogens? Plasmalogens are unique phospholipids found in cell membranes, particularly in the brain, heart, and liver. Unlike most phospholipids, plasmalogens contain a vinyl ether bond in the sn-1 position of the glycerol backbone. The Importance of Plasmalogens Plasmalogens play several key roles in cellular function, including: Serving as a source of energy for cells Exhibiting antioxidant properties, protecting cells against oxidative stress Plasmalogens and Disease Studies have shown that a decrease in plasmalogen levels is associated with several diseases, including: Alzheimer's disease Cardiovascular disease Nonalcoholic fatty liver disease.

• Plasmalogen deficiency and neuropathology in Alzheimer’s disease: Causation or coincidence? Alzheimer’s & Dementia TRCI 5: Doi 10.1016/j.trci.2019.08.003
• Relation of Serum Plasmalogens and APOE Genotype to Cognition and Dementia in Older Persons in a Cross-Sectional Study. Brain Sci 9: Doi 10.3390/brainsci9040092
• Metabolic dysfunctions in multiple sclerosis: implications as to causation, early detection, and treatment, a case control study. BMC neurology, 15, 154. doi:10.1186/s12883-015-0411-4
• Metabolic system alterations in pancreatic cancer patient serum: potential for early detection. BMC Cancer 13: 416 Doi 10.1186/1471-2407-13-416
• Circulating plasmalogen levels and Alzheimer Disease Assessment Scale-Cognitive scores in Alzheimer patients. J Psychiatry Neurosci 35: 59-62
• Peripheral ethanolamine plasmalogen deficiency: a logical causative factor in Alzheimer’s disease and dementia. J Lipid Res 48: 2485-2498 Doi 10.1194/jlr.P700023-JLR200
• Pancreatic cancer serum biomarker PC-594: Diagnostic performance and comparison to CA19-9. World J Gastroenterol 21(21): 6604-6612
• Low-serum GTA-446 anti-inflammatory fatty acid levels as a new risk factor for colon cancer. Int J Cancer 132: 355-362 Doi 10.1002/ijc.27673
• Metabolic system alterations in pancreatic cancer patient serum: potential for early detection. BMC Cancer 2013, 13:416
• Human serum-derived hydroxy long-chain fatty acids exhibit anti-inflammatory and anti-proliferative activity. J Exp Clin Cancer Res 30: 59 Doi 10.1186/1756-9966-30-59
• Reduced levels of hydroxylated, polyunsaturated ultra long-chain fatty acids in the serum of colorectal cancer patients: implications for early screening and detection. BMC Med 8: 13 Doi 10.1186/1741-7015-8-13
• Reduction of novel circulating long-chain fatty acids in colorectal cancer patients is independent of tumor burden and correlates with age. BMC Gastroenterol 10: 140 Doi 10.1186/1471-230X-10-140
• Serum Metabolite Profiling for the Detection of Pancreatic Cancer: Results of a Large Independent Validation Study. Pancreas. 2016;45:1418-23.
• Metabolic system alterations in pancreatic cancer patient serum: potential for early detection. BMC Cancer. 2013;13:416.

2:00 What is a plasmalogen

6:00 White matter tracks

7:26 neuron to neuron signaling

9:06 plasmalogen precursors

9:51 Alzheimer’s and brain reserve capacities

10:22 bio chemical reserve capacity

13:30 having high plasma allergens is a 30 year life expectancy difference

18:00 autism

19:12 MS

20:38 concussions

21:33 omega-3‘s

21:50 omega 9’s

24:40 Why inflammation is a perfect storm and actually feeds upon itself

25:38 rather than trying to suppress the inflammation we want to pull the log out of the fire

29:13 concussions and CTEs

34:15 new advance magnetic resonance imaging called diffuser tensor imaging. Used to measure white matter integrity

Now we can actually measure the water inside the copper wire and the water in the white matter sheath around it and the water outside of that

36:29 your brain never recovers from a concussion it just adapts

38:00 omega nine, and acetylcysteine, carnotine

39:09 in animal studies of brain degeneration, if we pre-treat them with plasmalogen precursors, we can’t actually cause brain damage

42:42 Amaloyd deposition in Alzheimer brains. Related to membrane structure and function

49:24 disease does not take your health away. Your health goes away and disease comes in

50:45 I actually painted a metaphorical analogy that he said he was going to steal!

52:44 function versus biomarkers or having “Tom Brady on the field”

53:50 functionality is the end all

55:00 plasmalogens and cancer

55:46 the Braca protein

58:20 exercise is bad for you. Recovering from exercise is great for you

1:00:30 the reason fasting is so insanely good for us

1: 11:03 What should we eat to help the plasma legend process

1:12:48 importance of membrane structure and

1:15:50 vision back to where it was when he was in his early 20s 1:17:59 the importance of the prodrome scan

1:23:06 his thoughts on intermittent fasting

1:25:02 Gerber sooth

1:26:00 lactobacillus rheuteri

1:31:24 peptides

1:31:35 Dr William Seeds

1:35:49 how a fighter can protect his or her brain before the battle

1:36:2038 APOE4 geno-type and amoloyd plaque

1:37:05 you can neutralize this genotype

1:45:14 Amaloid plaque is actually a biomarker of plasmalogen deficiency

1:45:28 if you have high plasmalogen levels you have low Amaloyd levels

1:45:34 Plasmalogens turn on the turn on Alpha secretase enzyme

1:46:18 HIGH PLASMALOGENS LEVELS NEUTRALIZE THE GENETIC RISK OF THE APOE4 GENOTYPE

1:51:02 neurofibrillary tangles

1:54:46 changing the bio markers without changing the cause Of the biomarker is done across our medical platform and has virtually no long-term clinical benefit

1:55:58 inflammation

2:04:33 his personal progression in medicine, why he dedicated his life to this and his philosophy

2:28:21 Prodrome Sciences